419 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study demonstrates that epithelial cell jamming is regulated by a metabolic-to-mechanical feedback loop, where crowding-induced mitochondrial pyruvate anaplerosis triggers RhoA-myosin II-driven cytoskeletal remodeling and macropinocytosis to control tissue fluidity.
This study reveals that the *C. elegans* dynamin homolog DYN-1, traditionally associated with vesicular trafficking, plays a critical and previously unrecognized role in mitosis by regulating the localization of SPD-2 and PLK-1 to ensure proper spindle pole organization and midbody assembly.
This study reveals that while the internalization of small extracellular vesicles (sEVs) is inefficient, the subsequent cytosolic delivery of their embedded syntenin cargo is highly efficient and governed by specific molecular determinants, challenging prevailing views on sEV-mediated communication.
This study demonstrates that the loss of the cell cycle regulator p27Kip1 is sufficient to drive metabolic reprogramming in untransformed cells, inducing a Warburg effect and glutamine addiction through extensive transcriptional remodeling of metabolic genes.
This study demonstrates that the yeast DENN domain protein Avl9 functions as a novel regulator in the recycling of endosomal cargos, such as Snc1, by acting in conjunction with multiple distinct recycling pathways rather than directly mediating secretory traffic from the TGN to the plasma membrane.
The paper introduces HFinder, a deep learning-based framework that automates the detection, segmentation, and quantitative analysis of plant-microbe interfaces in confocal images, thereby overcoming previous qualitative limitations to enable systematic, scalable studies of subcellular dynamics during infection.
This study demonstrates that adult mouse bone marrow contains previously unrecognized Cdh5/VE-Cadherin+ hemogenic endothelial cells capable of generating functional hematopoietic stem and progenitor cells and mature blood cells, thereby challenging the dogma that adult hematopoiesis is solely sustained by pre-existing stem cells.
This study presents an optimized, high-throughput luminescence assay utilizing syringe filtration and stabilization buffers to enable robust, specific, and time-flexible quantification of extracellular ATP in human airway epithelial cell cultures and bronchoalveolar lavage fluid, thereby facilitating advanced research into purinergic signaling in respiratory health and disease.
This study demonstrates that the highly metastatic MDA-MB-231 breast cancer cells respond to CXCL12 gradients in 3D collagen matrices with directed migration that is significantly influenced by cell morphology, particularly in denser matrices.
This study reveals that human naive CD4 T cell aging is driven by a transcriptional "overmaturation" trajectory, where age-associated changes exaggerate normal post-thymic maturation programs, leading to functional decline and immunosenescence.